I know its a supposed small risk, but thanks to Google I've uncovered some horror stories about vision issues after just 8mo-1yr and people swearing it is actually not uncommon. I've had the worst flare of my life over late summer, I've had 3 early miscarriages in 1.5 years, I'm almost always in some type of achy state or dead tired. Potential side effects and very real risks make the medication seem ridiculously dangerous. I'm not as familiar with MCTD but what I do know is that is can be just as dangerous as SLE. Is the vision loss something that will stop if the medication is stopped? Chloroquine and malaria Hydroxychloroquine & methotrexate Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. I'm back on it and waiting the 3-4 months it takes to work at least that's how long it took the first time. I have a great opthamologist who has assured me he will catch retinal damage before I will ever notice a change in my vision, so as far as I'm concerned, I want to stay on Plaquenil until I'm forced off it. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Your external symptoms are a sign that something very wrong is going on inside you. Why in the world would anyone choose to poison themselves? You have a choice to make between letting your disease run rampant and continue to damage your body until it can no longer fight back or using one of the few weapons you have at your disposal to slow it down. Unfortunately, you have to roll the dice and decide which risk you'd rather take. How long is plaquenil good Hydroxychloroquine Plaquenil -, Plaquenil Drug and Medication User Reviews on RxList Hydroxychloroquine routine labs Overall Plaquenil did take away the muscle and joint pain. It worked wonders for that. For that reason I am satisfied with plaquenil for what I took it for. Took about 5-6 months to see full effect. Since reducing the dose from 400mg to 200mg 4 months ago I do feel some of this pain returning You win some, you lose some! M 49 1 years 400mg day PLAQUENIL Side Effects, Reviews by Patients -. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. How effective is Plaquenil for Fibromyalgia by duration.. I know I've asked this question before, but with so many new people and so much time that's passed, I thought I'd ask again. How long did it take for Plaquenil to become effective for you? Meaning, when did you start to feel some relief from your lupus symptoms after you started taking. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Of all the drugs I've had to take for lupus, plaquenil is probably the most mellow. It is my understanding that if it affects your eyes, it's a slow onset type thing, so if you're having your eyes checked regularly every 6mos, you will be fine.