I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Hydroxychloroquine copay assistance program Plaquenil sulfa drug Plaquenil brand name covered by insurance aetna Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. What is Hydroxychloroquine, and What Does It Do? According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Hydroxychloroquin and methotrexate Hydroxychloroquine Side Effects Common, Severe, Long Term., Compare Plaquenil vs Methotrexate - Uses for plaquenilPlaquenil seronegatice raDrugs for ra plaquenil andScreening criteria for ocular toxicity of plaquenilPlaquenil wonder drug Hi Everyone, I went to my Rheumatologist last week. She is giving me and my gastro. dr. a choice between Plaquenil and Methotrexate. One affects your eyes more and one affects your liver more. That is what my dr. said. So, what do yall know about the side effects of both and the benefits of both? I would appreciate any Which would you pick and why? - Plaquenil or Methotrexate. RA and Hydroxychloroquine How Effective is it for.. Hydroxychloroquine oral and methotrexate sodium oral Drug.. Summary Drug interactions are reported among people who take Hydroxychloroquine sulfate and Methotrexate together. This study is created by eHealthMe based on reports of 5,663 people who take Hydroxychloroquine sulfate and Methotrexate from Food and Drug Administration FDA, and is updated regularly. With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.