Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil dosage based on weight Plaquenil dark skin Therefore Plaquenil should not be used in pregnancy. Lactation Careful consideration should be given to using hydroxychloroquine during lactation, since it has been shown to be excreted in small amounts in human breast milk, and it is known that infants are extremely sensitive to the toxic effects of 4-aminoquinolines. Based upon what you both report, it sounds like you should have if you can notice something within days of changing just a portion of the dose. Good luck today. I'd be interested in hearing what he says, since Plaquenil is not known for effecting the heart, etc like you report. But a new study involving a commonly prescribed muscle relaxant suggests patients may not be getting what they think they are getting when they split pills. In pill splitting, a doctor may prescribe a pill with double the needed dose of medication, telling the patient to split the pills and only take half of a pill. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Why plaquenil should not be cut in half When It's Safe to Split Pills - Consumer Reports, Let me tell you what weaning down from Plaquenil is like. 5 year plaquenil protocolWhat is chloroquine resistanceHigh triglycerides and plaquenilHydroxychloroquine sulfate discount card Which is mostly why I am taking it also so I have my fingers crossed there. I just started and I am cutting my 200tmg pill in half and only taking the 1/2 for a couple of weeks per my rheumys recommendation as it causes stomach upset at first. I would say try it again but only start with 100mg, not the whole 400, Tried plaquenil 200mg 2 tablets at once and got very sick.. Cutting Pills in Half Could Pose Problems. Plaquenil Uses, Dosage & Side Effects -. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. Why did you cut your dose down if I may ask? Barbara/Tmir. Barbara, I started the antibioitic protocal about six years into the disease and started feeling better so I cut my Plaquenil doseage in half. My rheumo said not to do this until my labs returned to normal, but since they were close I did it anyway. Plaquenil film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. For radical cure of P. vivax and P. malariae infections, concomitant therapy with an 8-aminoquinoline compound is necessary.