Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil and early menopause Plaquenil tremors Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Plaquenil can change the pigmentation in the skin, so it would stand to reason that it can do the same with hair. I have experienced the change in pigmentation on my legs. It looks like I have a huge bruise on the back of my leg which extends from the calf to the ankle. I call it a perma-bruise. Most people who take Plaquenil also take other medicines for pain and stiffness. How does Plaquenil work? Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. How do you take Plaquenil? Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil skin changes The Risk of Retinal Toxicity with Plaquenil, Plaquinel changes hair color?" Lupus Community - Support Group Deae dextran chloroquine method Sep 21, 2018 Your doctor may diagnose morphea by examining the affected skin and asking you about your signs and symptoms. He or she may take a small sample of the affected skin skin biopsy for examination in the laboratory. This may reveal changes in your skin, such as thickening of a protein collagen in the second layer of skin dermis. Morphea - Diagnosis and treatment - Mayo Clinic. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Jul 29, 2019 Few medicines change the color of your hair and skin and even eye but only as a side effect. To use such drugs with the sole purpose of changing hair color would be totally inappropriate and dangerous. I would like to add that, medicines are not meant to change the physical appearance of a person. They are just intended to treat or prevent. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear.