Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Chloroquine trade name Hydroxychloroquine for sjogren's syndrome vs another drug Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Hi San It's great to hear from you again! Sorry to hear that you're worried about being prescribed Hydroxychloroquine Plaquenil. I'm not on this drug myself so can't give you any first hand experience but I know many of our members are using it and a lot of them seem to have had very satisfactory results from it. Because limited scleroderma can affect different parts of your body, you might need to consult with a variety of doctors, including those who specialize in the treatment of arthritis and other musculoskeletal disorders rheumatologist, skin disorders dermatologist or lung disorders pulmonologist. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil forlimited sclera derma Scleroderma Treatment Options Johns Hopkins Scleroderma., Hydroxychloroquine? - UK Scleroderma - Sclero Forums Plaquenil generic alternativesChloroquine phosphate adverse effectsIcd 10 code for high risk medication plaquenilDoxycycline and plaquenilAtrovent and plaquenil Although these aren't approved for scleroderma, doctors often prescribe them to help. At-Home Treatments, Physical Therapy, and Surgery If you have Raynaud's phenomenon, wear gloves and warm socks. Understanding Scleroderma -- Diagnosis and Treatment. Limited scleroderma - Diagnosis and treatment - Mayo Clinic. My Approach to the Treatment of Scleroderma. About Scleroderma Scleroderma is a connective tissue disease that involves changes in the skin, blood vessels, muscles, and internal is a type of autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. My 7 year old daughter has been on Plaquenil for almost 2 years now. It is considered a disease modifying drug, but not an immunosuppressant. My daughter has never complained of fatigue or stiffness, but that might be because we caught the disease early on, and the medication has prevented it from the start. ThisGerman S1-guideline proposes a classification of localized scleroderma that, considering the extent and depth of fibrosis, distinguishes limited, generalized, linear, and deep forms of localized scleroderma, together with its associated subtypes.