Why chloroquine is given in loading dose

Discussion in 'Canadian Pharcharmy' started by Sparrow, 19-Mar-2020.

  1. moneygate XenForo Moderator

    Why chloroquine is given in loading dose

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Inappropriate loading dose reduction resulting in ineffectively low plasma concentration is a significant danger in patients with renal impairment. A single loading dose of antibiotic, equivalent to the usual maintenance dose for patients with normal renal function, should almost always be given to patients with impaired renal function. What I’m wondering is if there is any relationship with increasing the loading dose and the time taken to reach the steady state. For example, if a greater loading dose was given for a particular drug, would this decrease the time taken to reach the steady state compared to smaller loading dose? Thank you very much in advance. Kind Regards, Sarah The loading dose is administered in order to achieve a therapeutic amount in the body more rapidly than would occur only by accumulation of the repeated smaller doses. The smaller doses D which are given after D* are called “maintenance doses”.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Vancomycin loading dose - the pharmacokinetics to consider., What is a Loading Dose? – Certara

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  6. Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults.

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    Dosage. Chloroquine can be administered either orally or parenterally for treatment of malaria, but prophylaxis is given in tablet form. An effective blood concentration is reached within 2-3 hours if a loading dose of 600 mg base is used. By the time the government approves any vaccination, the damage by COVID-19 will be done. Why not use something we have available already? Chloroquine. It was cheap and readily available. South Korea included it’s use in their guidelines, and they had an order of magnitude fewer deaths than China! An Effective Treatment for COVID-19 To avoid nausea and vomiting chloroquine should be administered after meals. If part or all of a dose is vomited, the same amount must immediately be readministered. Adults, including pregnant women, and children Total dose 25 mg/kg given over 3 days. Day 1 10 mg/kg, followed by 5 mg/kg 6-8 hours later. Days 2 and 3 5 mg/kg in a single dose.

  7. NCI XenForo Moderator

    Our free Discount Rx savings card can help you and your family save money on your prescriptions. Chloroquine Dosage & Rx Info Uses, Side Effects Tafenoquine Dosage Guide with Precautions - Mefloquine Dosage Guide with Precautions -
  8. panker Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. A New Synthesis of Chloroquine - Journal of the American. Action of chloroquine on in vivo RNA and protein biosynthesis. Cell wall Synthesis Inhibitors and their Mode of Action.
  9. Fitis XenForo Moderator

    Erosive Inflammatory Osteoarthritis Symptoms, Diagnosis. Jul 18, 2018 Erosive inflammatory osteoarthritis symptoms tend to begin suddenly. Many people report severe tenderness in the finger joints, along with stiffness, swelling, redness, and warmth. This is different than the gradual onset of symptoms that are usually seen in those who are suffering from typical osteoarthritis.

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