Clinical trials cancer chloroquine

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  1. Mizhgan Guest

    Clinical trials cancer chloroquine


    Listing a study does not mean it has been evaluated by the U. One of the mechanisms responsible for survival of these therapy-resistant hypoxic cells is (macro-)autophagy: a phenomenon in which cells provide themselves with energy (ATP) by digesting their own cell-organelles. Tumor hypoxia is a well-known factor negatively influencing outcome in many solid tumors, including small cell lung cancer.

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    Jul 15, 2014 Along the lines of the Trial Watch series published on a monthly basis in OncoImmunology,35-38 here we summarize the dual role of autophagy in oncogenesis and tumor progression and discuss recent clinical trials investigating the use of chloroquine CQ, hydroxychloroquine HCQ in cancer patients. Apr 11, 2012 Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer Chloroquine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers.

    Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy.

    Clinical trials cancer chloroquine

    Chloroquine Clinical Trials, Side Effects AIDSinfo, Chloroquine as an Anti-autophagic Radiosensitizing Drug in.

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  5. Adjuvant Effect of Chloroquine on Gemcitabine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government.

    • Adjuvant Effect of Chloroquine on Gemcitabine - Full Text..
    • Re-purposing Chloroquine for Glioblastoma Potential Merits..
    • Chloroquine in cancer therapy a double-edged sword of autophagy..

    Abstract. The PINC trial NCT01023477 examined the dosage efficacy of oral chloroquine CQ, an autophagy inhibitor, as a neoadjuvant therapy to reduce the volume, cause regression and decrease the recurrence of breast ductal carcinoma in situ DCIS, for any grade or ER/PR/Her2 status. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the other hand, however, the kidneys are highly vulnerable to chemotherapeutic agents. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy.

     
  6. dabinx Guest

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine - Side Effects, Dosage, Interactions. Plaquenil Hydroxychloroquine Side effects, Images, Uses. Mylan-Hydroxychloroquine - Uses, Side Effects.
     
  7. replayer User

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine Side Effects, Dosage, Uses, and More Intravenous pulses of methylprednisolone for systemic. Can you take CBD oil with Prednisone? - JustAnswer
     
  8. Xoxol Moderator

    Allergic reaction to Plaquenil Lupus Forums at The Lupus Site I have started Plaquenil 3 weeks ago and the last week developed a rash all over sounds exactly like yours burning and itching but nothing on my face so I was doubting that it could be a lupus rash. Rhema appointment is still a month away and the rash is getting worse by the day.

    Hydroxychloroquine-induced dark butterfly rash in a.
     
  9. Xargon Moderator

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