Acute chloroquine toxicity

Discussion in 'Chloroquin' started by WRX, 12-Mar-2020.

  1. BugTrapper Moderator

    Acute chloroquine toxicity


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

    Hydroxychloroquine methotrexate drug interactions Plaquenil excretion

    Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. CONCLUSIONS The mortality rate in patients with acute chloroquine poisoning, including those patients sick enough to be referred to a specialty unit such as ours, can be limited to or = 10%. This finding appears to be true even in patients with massive ingestions. The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Acute chloroquine toxicity

    Chloroquine and Hydroxychloroquine Toxicity Practice., Treatment of acute chloroquine poisoning a 5-year experience.

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  7. Children aged under 6 years of age should not be given chloroquine due to the risk of overdose and acute toxicity. The chloroquine dose should be reduced in patients with renal disease, as up to 70% of chloroquine is excreted unchanged in the urine. Chloroquine itself can cause reduced kidney function of up to 10% of patients, especially in those over 60 years of age.

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    Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. In acute attacks of malaria, chloroquine interrupts erythrocytic schizogony of the parasite. its ability to concentrate in parasitized erythrocytes may account for its selective toxicity against the erythrocytic stages of plasmodial infection. Chloroquine CQ and hydroxychloroquine HCQ are anti‐rheumatic medications frequently used in the treatment of connective tissue disorders. We present the case of a 45‐year‐old woman with CQ‐induced cardiomyopathy leading to severe heart failure.

     
  8. brutbarry XenForo Moderator

    Description: An exception occurred while processing your request. The Risk of Retinal Toxicity with Plaquenil - Sjogren's Hydroxychloroquine And Chloroquine Screening 2016 AAO Recommendations. Visual Fields and Plaquenil Medical Billing and Coding Forum - AAPC
     
  9. arm777 XenForo Moderator

    Plaquenil (hydroxychloroquine) is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Healthboards - Immune & Autoimmune - Lupus Plaquenil and. Lupus Medicines Hydroxychloroquine - Brigham and Women's. Ask the Expert Plaquenil and Sjögren’s
     
  10. Serega_PlayBoy Moderator

    Aplastic anemia - Symptoms and causes - Mayo Clinic Jan 11, 2020 Aplastic anemia develops when damage occurs to your bone marrow, slowing or shutting down the production of new blood cells. Bone marrow is a red, spongy material inside your bones that produces stem cells, which give rise to other cells. Stem cells in the bone marrow produce blood cells — red cells, white cells and platelets.

    Plaquenil - FDA prescribing information, side effects and uses
     
  11. Xaero User

    Hydroxychloroquine Plaquenil The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses