Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil cause weight loss or weight gain Does plaquenil help sjogren& 39 Most of the medications used for treatment of RA have potential toxicities, though Plaquenil is widely believed not to add significant risk to surgery and to wound healing. The lower the prednisone dose, the better. Aug 21, 2014 There are several risks involved with breast reduction surgery. They can involve the following infection, bleeding issues, reaction to anesthetic, uneven breast, nipple problems and nipple numbness. Breast reduction surgery holds many risks. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and surgery risk Plaquenil Oral Uses, Side Effects, Interactions., What are the risks of dental surgery while taking plaquenil. Chloroquine reviewsHydroxychloroquine arthritis research Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. The Risk of Retinal Toxicity with Plaquenil. Rx Side Effects New Plaquenil Guidelines and More - American.. Perioperative Management of Medications Used in the.. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.