It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine skin discoloration Plaquenil associated hyperpigmentation Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Hydroxychloroquine Plaquenil and prednisone are considered safe during pregnancy. Methotrexate and cyclophosphamide Cytoxan should not be used in pregnancy and should be discontinued for at least a month prior to getting pregnant. Ask your doctor to help you weigh the benefits and risks all your medications. Safety of antiinflammatory and immunosuppressive drugs in rheumatic diseases during pregnancy and lactation View in Chinese generally considered safe. The following medications are viewed as relatively safe in pregnancy Hydroxychloroquine HCQ Sulfasalazine SSZ Low-dose aspirin Pregnancy – HCQ can be continued during The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine during pregnancy Hydroxychloroquine Oral Uses, Side Effects, Interactions., Lupus and Pregnancy Tips for Living with Lupus While Pregnant Retinal damage caused by hydroxychloroquineLong term effects hydroxychloroquine Hydroxychloroquine is usually considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using hydroxychloroquine during pregnancy see Plaquenil and Pregnancy for more information. Precautions and Warnings With Hydroxychloroquine. UpToDate. Safety of hydroxychloroquine in pregnant patients with.. DÜSSELDORF, GERMANY — The anti-inflammatory compound hydroxychloroquine appears to be relatively safe during pregnancy, according to a small number of studies totaling about 250 patients. But these studies have not provided overwhelming evidence proving the safety of this agent in pregnancy, Jean-Charles Piette, M. D. said at an international conference on cutaneous lupus erythematosus. Infants exposed to hydroxychloroquine during breastfeeding receive only small amounts of the drug in breastmilk. In infants up to at least 1 year of age, careful follow-up found no adverse effects on growth, vision or hearing. International experts indicate that hydroxychloroquine is acceptable during breastfeeding. Background/Purpose Chloroquine CQ and Hydroxychloroquine HCQ have been used for years during pregnancy for multiple indications malaria prevention, autoimmune disorders, etc. Recently, some countries face restrictions to prescribe these drugs during pregnancy, due to report of ocular toxicity in animal models and potential genotoxicity.