Hydroxychloroquine lysosome blocker

Discussion in 'Chloroquine Drug' started by Elenа, 21-Feb-2020.

  1. tutanxamon XenForo Moderator

    Hydroxychloroquine lysosome blocker


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. Dec 17, 2019 ATLANTA – Hydroxychloroquine Plaquenil 400 mg/day starting by pregnancy week 10 reduces recurrence of congenital heart block in infants born to women with anti-Ro antibodies, according to an open-label, prospective study presented at the annual meeting of the American College of Rheumatology. Oct 15, 2012 Hydroxychloroquine HCQ is a 4-aminoquinoline which differs from chloroquine CQ in the addition of a hydroxyl group. Initially used as antimalarials, both drugs have now become mainstays in the management of rheumatic diseases principally systemic lupus erythematosus SLE and rheumatoid arthritis RA.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Hydroxychloroquine lysosome blocker

    Hydroxychloroquine Oral Uses, Side Effects, Interactions., Hydroxychloroquine prevents congenital heart block recurrence.

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  5. DIAGNOSIS. Hydroxychloroquine myopathy. DISCUSSION. Hydroxychloroquine HCQ, a commonly used drug for various autoimmune conditions, is widely distributed into cardiac and skeletal muscle tissue. It is a large amphiphilic molecule that can cause both myofiber necrosis and vacuolar myopathy.

    • Final Diagnosis -- Hydroxychloroquine myopathy - UPMC.
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    Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells PDCs. citation needed Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process. May 24, 2019 The risk may also be higher with some doses of hydroxychloroquine, if you use hydroxychloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight changes like blurred or foggy eyesight, trouble focusing or reading, or trouble seeing in dim light. The second trial was also a small randomised, double-blinded trial, comparing the effectiveness of hydroxychloroquine with that of zidovudine monotherapy for 16 weeks in 72 patients, 64 of whom being antiretroviral treatment-naive 35 in the hydroxychloroquine arm and 37 in the zidovudine arm.

     
  6. ChAOTIK Well-Known Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Why Can't I Get Better, a Book Summary for Lymie Brains Plaquenil hydroxychloroquine sulfate dosing, indications. LymeMD Lyme and Bartonella A Tale of Two Herxes
     
  7. muraha Moderator

    Plaquenil Prices, Coupons & Patient Assistance Programs - Plaquenil Prices, Coupons and Patient Assistance Programs. Plaquenil hydroxychloroquine is a member of the antimalarial quinolines drug class and is commonly used for Dermatomyositis, Lyme Disease - Arthritis, Malaria, and others.

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