In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Hydroxychloroquine cream Plaquenil baseline eye exam Chloroquine method of action Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Desorption of chloroquine and hydroxychloroquine from Sepia melanin. Initially 5 mg of melanin was saturated by equilibration with 5 mL of 1.9 mmol/L chloroquine prepared in 20 mM potassium phosphate buffer at pH 7.4 for 2 h. The samples were then centrifuged at 477 × g for 4 min and the supernatant removed. Changes of the skin and mucus membrane during the course of chloroquine therapy for connective tissue disorders. These female patients developed hyper pigmentation of the skin, largely on the exposed parts Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Chloroquine skin pigmentation Chloroquine - Wikipedia, Chloroquine and hydroxychloroquine binding to melanin. How long does it take for plaquenil to start workingWithdrawal from plaquenilPlaquenil 200 mg en españolPatients assistance for hydroxychloroquine Chloroquine has affinity for melanin and it gets con- centrated in pigmented melanin-containing structures which may explain its toxic effects on the eye kerato- pathy and retinopathy and that on the skin when used Hyperpigmentation of the Skin Following Chloroquine.. Hyperpigmentation of the Skin Following Chloroquine Treatment.. Pathological pigmentation of the skin and palate caused by.. Tell your doctor if you have or have ever had liver disease, psoriasis, porphyria or other blood disorders, G-6-PD deficiency, dermatitis skin inflammations, or if you drink large amounts of alcohol. tell your doctor if you have ever had vision changes while taking hydroxychloroquine, chloroquine Aralen, or primaquine. There is an unusually high affinity for melanin-containing cells eg, in the skin and retina. Deposits in these cells can lead to cutaneous pigmentation and possibly retinal toxicity. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. They were flat without induration or scaling. A diagnosis of HCQ-associated hyperpigmentation was made, and HCQ was discontinued.