It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Vd chloroquine Chloroquine resistance map malaria 2015 Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Mar 21, 2016 Sorry in advance if this is stupid. I have noticed that I can tolerate antibiotics by themselves just fine. I can even handle the addition of plaquenil to antibiotics. But every time I try to add in a second antibiotic like bactrim, ceftin or antifungal like Tinidazole, my insomnia comes back as well as my urinary issues. I have just been reading that plaquenil can cause insomnia and nightmares which I suffer with. I take my plaquenil with my evening meal. When is the best time to take it? Would it be best in the morning? I also take in the morning thyroxine, omeprazole and co-codamol, would it interfere with any of those if I took it in the morning instead of. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil cause insomnia Started taking Plaquenil for Lupus and now I can't sleep. Any., Is this a herx? Bladder issues and insomnia Does hydroxychloroquine cause human birth defects If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. Other Medicines That Might Trigger a Flare. A few other drugs to discuss with your doctor include Drugs & Medications That Can Trigger Psoriasis Flare-Ups. When best time of day to take plaquenil? - LUPUS UK. Plaquenil. Some common RA medications may also contribute to sleeplessness. One is the steroid prednisone, which can cause insomnia, agitation or depression. Taking it earlier in the day is best, says Dr. Rosian. Another is hydroxychloroquine Plaquenil. It can sometimes causes people to get jumpy, nervous and twitchy. Fragmented Sleep Sjogren's certainly can cause pain and fatigue. But when the pain is widespread and insomnia is present, I find that a secondary fibromyalgia is usually also present – and treating this can result in dramatic improvement. Treatment for Dry Eyes and Mouth First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed. When I started taking Plaquenil, I got a bit depressed but that's not a big deal.