It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine for inflammatory arthritis Chloroquine storage in retina Eye 5est to check eyes when taking plaquenil Hydroxychloroquine lupus pregnancy A, Bluish-green pigmentation on the legs in a patient with systemic lupus erythematosus without lupus lesions at the time of the skin biopsy. B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. Vision changes/loss of vision There is a chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. This is called known as hydroxychloroquine retinopathy. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Skin changes with plaquenil Taking Plaquenil for Rheumatoid Arthritis, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Side effects from taking plaquenilHydroxychloroquine remission early onset rheumatoid arthritisCan i take plaquenil for heart attack Your doctor may diagnose morphea by examining the affected skin and asking you about your signs and symptoms. He or she may take a small sample of the affected skin skin biopsy for examination in the laboratory. This may reveal changes in your skin, such as thickening of a protein collagen in the second layer of skin dermis. Morphea - Diagnosis and treatment - Mayo Clinic. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Skin Pigmentation with Hydroxychloroquine Plaquenil.. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Plaquenil can change the pigmentation in the skin, so it would stand to reason that it can do the same with hair. I have experienced the change in pigmentation on my legs. It looks like I have a huge bruise on the back of my leg which extends from the calf to the ankle. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes.