It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine inhibits How to pronounce plaquenil When does plaquenil start working Plaquenil and ringing in ears Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Rare but potentially serious eye toxicity can occur. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. May 04, 2015 Confirmed Plaquenil Muscle Toxicity - Scleroderma. Just got back from my neurologist and I am officially a "zebra" - my extreme and fast developing proximal muscle weakness myopathy is from Plaquenil. It doesn't mean I don't have any muscle weakness from the scleroderma, but the crazy, out-of-control weakness was from Plaquenil. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Hydroxychloroquine muscle toxicity Plaquenil Oral Uses, Side Effects, Interactions., Hydroxychloroquine-Induced Retinal Toxicity - American. Hydroxychloroquine 400 mg tabletsHydroxychloroquine monitoring bloods Many drugs used for therapeutic interventions can cause unanticipated toxicity in muscle tissue, often leading to considerable morbidity. A drug-induced, or toxic, myopathy is defined as the acute or subacute manifestation of myopathic symptoms such as muscle weakness, myalgia, creatine kinase elevation, or myoglobinuria that can occur in patients without muscle disease when they are exposed. Drug-related Myopathies of Which the Clinician Should Be Aware. Confirmed Plaquenil Muscle Toxicity - Scleroderma - Inspire. Hydroxychloroquine-Induced Toxic Myopathy Causing.. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Toxicity may be more likely in patients with renal or hepatic disease, advanced age, or on chronic drug therapy. Hydroxychloroquine myopathy presents with proximal muscle weakness and normal to mildly elevated creatine kinase levels. There are very few reported cases of ventilatory failure due to HCQ myopathy 2, 3. Hydroxychloroquine is the most commonly used AM, specifically because it has a lower risk for retinal toxicity than chloroquine. This may be because CQ crosses the blood-retinal barrier and HCQ does not. There is no retinal damage associated with the use of quinacrine.