I remember the crushing fatigue and hope that I never have to feel that way again. I was on Plaquenil for over a year with my Limited Systemic Sclerosis and didn't notice any effect, scleroderma still progressing. :( Next week I am going to consult with my scleroderma doc what next. It's generally prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. I remained on that dosage for the first five years. You have to have you eyes checked on a very regular basis as it can cause visual changes and difficulty. Can plaquenil cause low blood pressure Dosage for plaquenil I started generic plaquenil mid-may. I feel good but wonder if I will be able to cut the dose from 200 mg. twice a day and how long I have to be on it. Or if i can just take it when neccesary. My doctor is in the process of being absorbed into another medical group and is hard to reach for now. Adults—At first, 400 to 600 milligrams mg taken as a single dose or in two divided doses once a day. Then, 200 to 400 mg taken as a single dose or in two divided doses once a day. Your doctor may adjust your dose if needed. However, dose is usually not more than 600 mg or 6.5 mg per kilogram kg of body weight per day, whichever is lower. Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. But it had an almost immediate effect for me with respect to fatigue, which I attribute to it's effect on vitamin D regulation (or dysregulation in my case). There have been times when I've stopped taking it over the years and have noticed no change in my fatigue or pain levels. The swelling/tendonitis in my fingers & toes stopped progressing after about 3 months, but 9 months later, they are still somewhat stiff and swollen, so it's difficult to know what would have happened without it. After that I was dropped to 200 mg two times a day. It's been a long time since I began taking it, but I don't remember any increase in energy. 200 mg of plaquenil how long to work How long does it take for plaquenil hydroxychloroquine to., Hydroxychloroquine Oral Route Proper Use - Mayo Clinic Apo-hydroxychloroquine for swellingChloroquine purposeEye damage from plaquenil Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Hydroxychloroquine Plaquenil. How long did hydroxychloroquine take to work. - HealthUnlocked. Pharmacokinetics Following a single 200 mg oral dose of Plaquenil to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. A loading dose of 1,200 mg daily, given for 6 weeks may decrease the time to clinical response. However, experts debate that this higher dosage may increase the risk of toxicity. Hydroxychloroquine can be taken in a single or divided dose to control gastrointestinal side effects. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs.