One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine dosage sle Plaquenil ocular toxicity Of dropout in rheumatoid arthritis treatment with hydroxychloroquine Chloroquine phosphate dosage malaria prophylaxis Retinal toxicity associated with chronic exposure to hydroxychloroquine and its ocular screening. Review. the diffuse loss of fundus pigmentation makes the bull’s eye maculopathy hard to recognize. Severns ML. Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity a review of mfERG ring ratios in Plaquenil. Dr. Fung’s case involved a 48-year-old woman with lupus. Nine years after discontinuing medical therapy, the patient had new scotomas, difficulty reading and progression of bull’s-eye maculopathy. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Hydroxychloroquine Maculopathy An Update on Screening and Diagnosis A brief guide for imaging SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil bull's eye maculopathy Bull's-Eye Maculopathy NEJM, Rx Side Effects New Plaquenil Guidelines and More. Chloroquine raynauds Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. New Plaquenil Guidelines -. Retinal Physician - Hydroxychloroquine Maculopathy An.. Plaquenil Related Eye Problems - Fraser Eye. Hydroxychloroquine-Induced Retinal Toxicity; Ophthalmic Pearls. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. these findings do not explain the clinical pigmentary changes causing a bull’s-eye maculopathy. Bull’s eye maculopathy describes a number of different conditions in which there is a ring of pale-looking damage around a darker area of the macula. The macula can often appear to have circular bands of different shades of pink and orange. Age of onset and severity of sight loss varies, and it can be inherited in many ways. The condition sometimes resembles a target, or bulls-eye ring, on the retina surrounding the macula. Hydroxychloroquine retinopathy is extremely rare and is most often seen in cases where the dosage is high or the patient has been taking it for several years. Bulls-eye maculopathy is uncommon, but when it does occur, it can be devastating.