Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Natural alternative plaquenil Tylenol and hydroxychloroquine Plaquenil canada Treatment of plaquenil hyperpigmentation Jan 31, 2019 Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer. Trametinib and Hydroxychloroquine in Treating Patients with Pancreatic Cancer THREAD University of Utah / Novartis Pharmaceuticals Identifier NCT03825289 Trametinib PubChem CID 11707110 Huntsman Cancer Institute, University of Utah Photo National Cancer Institute Investigators at the Huntsman Cancer Institute at the University of Utah are conducting a Phase I clinical. Kinsey discovered through experimentation that the use of two pills — trametinib plus hydroxychloroquine — that are already available from two different classes of drugs, could potentially impact the process of abnormal cell division and growth caused by a genetic mutation that leads to pancreatic cancer, and increase a patient's lifespan. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Trametinib hydroxychloroquine Trametinib and Hydroxychloroquine in Treating Patients., Phase I Study of Trametinib and Hydroxychloroquine in. How to pronounce plaquenilChloroquine as antiamoebicPlaquenil et psoriasisIs it ok to drink alcohol while taking plaquenil Hydroxychloroquine is a 4-aminoquinoline in use for more than 30 years for the treatment of malaria, rheumatoid arthritis, and systemic lupus erythematosus. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. Phase Ib/II study of hydroxychloroquine in combination.. Utah researchers identify potential treatment for.. UPCC 02614 The BAMM Trial BRAF, Autophagy and MEK.. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer. This phase I / II trial studies the side effects and best dose of hydroxychloroquine when given together with dabrafenib and trametinib and to see how well they work in treating patients with stage IV melanoma that has spread to other places in the body. Sometimes when dabrafenib and trametinib are given, the tumor cells activate a stress response called autophagy. Autophagy provides resistance to dabrafenib and trametinib treatment over time making them less effective. Giving hydroxychloroquine with dabrafenib and trametinib may reduce drug resistance and allow more tumor cells to be killed.