Dark-skinned persons may experience generalized pruritus that is not indicative of drug allergy. Retinal toxicity that may occur with long-term high doses of chloroquine used in the treatment of other diseases is extremely unlikely with chloroquine given as a weekly malaria chemosuppressive agent. Does plaquenil help with inflammation Chloroquine phosphate injection dosage Plaquenil poisoning Hydroxychloroquine long qt Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. Chloroquine phosphate is a 4-aminoquinolone that acts by inhibiting heme polymerase. 198 Chloroquine is well tolerated and in appropriate doses may be safely used by young children and pregnant women. 199 Transient nausea or vomiting is seen in a small proportion of individuals and may usually be reduced by taking the drug with food. Occasionally, headaches or blurred vision are reported. Because insufficient drug is excreted in breast milk to protect the infant, nursing infants should be given chloroquine. Chloroquine use is suitable for people of all ages and for pregnant women. Chloroquin mechanism Chloroquine - FDA prescribing information, side effects and uses, Chloroquine - Wikipedia Chloroquine and beclinChloroquine effets secondairesChloroquine mechanism of action ppt Nov 15, 2015 However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others see below the section on mechanisms. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Chloroquine & Hydroxychloroquine supporting chemo.. Chloroquine - an overview ScienceDirect Topics. Hydroxychloroquine - Wikipedia. A brief presentation of chloroquine, its history and its future in the medical industry. Skip navigation. Chloroquine Mechanism of action and resistance in malaria 2 minutes Microbiology. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin.