Ongoing monitoring of blood counts, liver and kidney function is also required. Prescribed for Acute Lymphocytic Leukemia, Acute Lymphoblastic Leukemia, Rheumatoid Arthritis, Psoriatic Arthritis, Solid Tumors, Small Cell Lung Cancer, Systemic Sclerosis, Neoplastic Diseases, Trophoblastic Disease, Osteosarcoma, Non-Small Cell Lung Cancer, Non-Hodgkin's Lymphoma, Psoriasis, Mycosis Fungoides, Dermatomyositis, Breast Cancer, Choriocarcinoma, Meningeal Leukemia, Graft-versus-host disease, Head and Neck Cancer, Juvenile Idiopathic Arthritis, Lymphoma. How does plaquenil cause weight loss Hydroxychloroquine and rheumatoid arthritis Methotrexate allows about 30% to 50% of early RA patients to achieve a low disease activity. Among the several potential DMARD Disease Modifying Anti-Rheumatic Drugs combinations, the combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ has been shown to be the most effective. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 I've been taking plaquenil, methotrexate and sulfasalazine for many years now. I was terrified to take mtx in the beginning, so I understand why you'd like to put that off for now. I did the same thing and tried plaquenil first. " Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus. May also be prescribed off label for Bladder Cancer, Acute Nonlymphocytic Leukemia, Soft Tissue Sarcoma, Scleroderma, Pityriasis rubra pilaris, Pemphigus, Pemphigoid, Pancreatic Cancer, Ovarian Cancer, Mantle Cell Lymphoma, Brain Tumor, Bullous Pemphigoid, Cervical Cancer, Cogan's Syndrome, Colorectal Cancer, Ectopic Pregnancy, Eczema, Esophageal Carcinoma, Gastric Cancer, Hodgkin's Lymphoma, Uveitis. Methotrexate sulfasalazine and hydroxychloroquine Hydroxychloroquine Plaquenil RheumTutor, Treatments for Rheumatoid Arthritis Retail cost of plaquenilDesethyl chloroquineEffects of stop taking plaquenil TRIPLE THERAPY WITH METHOTREXATE, SULFASALAZINE, AND HYDROXYCHLOROQUINE IN PATIENTS WITH RHEUMATOID ARTHRITIS. This article primarily covers the author's experience with the use of the combination of methotrexate MTX, sulfasalazine SSZ, and hydroxychloroquine HCQ to treat patients with rheumatoid arthritis RA. TRIPLE THERAPY WITH METHOTREXATE, SULFASALAZINE, AND.. Taking plaquenil and sulfasalazine Arthritis Information. REFERENCES - UpToDate. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial, Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX.