Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine route of administration Minocycline plaquenil lyme Plaquenil whorl keratopathy The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. Cardiac Effects, including Cardiomyopathy and QT prolongation Postmarketing cases of life-threatening and fatal cardiomyopathy have been reported with use of Plaquenil as well as with use of chloroquine. Patients may present with atrioventricular block, pulmonary hypertension, sick sinus syndrome or with cardiac complications. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil visual side effects Plaquenil Side Effects on Your Eyes and Vision, Plaquenil - FDA prescribing information, side effects and uses Plaquenil side effects pregnancy The incidence of corneal changes and visual side effects appears to be considerably lower with hydroxychloroquine than with chloroquine. Retina Macula Edema, atrophy, abnormal pigmentation mild pigment stippling to a "bull's-eye" appearance, loss of foveal reflex, increased macular recovery time following exposure to a bright light photo. DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet. Plaquenil Side Effects - GoodRx. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Check with your doctor immediately if any of the following side effects occur Incidence not known. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hallucination, visual is found among people who take Plaquenil, especially for people who are female, 60+ old also take medication Lasix, and have Essential hypertension. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly.