Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine x ray structure Plaquenil brittle hair Lupus hydroxychloroquine sulfate Plaquenil and rheumatoid arthritis reviews View detailed reports from patients taking plaquenil who experienced neuropathy peripheral. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Mutations in the SCN9A or SCN10A gene can cause small fiber neuropathy. These genes provide instructions for making pieces the alpha subunits of sodium channels. The SCN9A gene instructs the production of the alpha subunit for the NaV1.7 sodium channel and the SCN10A gene instructs the production of the alpha subunit for the NaV1.8 sodium channel. MEDICATIONS THAT CAN CAUSE PERIPHERAL NEUROPATHY NAME OF MEDICATION COMMON BRAND NAMES USED TO TREAT Amiodarone Cordarone, Nexterone, Pacerone Abnormal heart rhythm. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause neuropathy Plaquenil Hydroxychloroquine - Side Effects, Dosage., Small fiber neuropathy - Genetics Home Reference - NIH Mylan hydroxychloroquine 200 mgDiscontinuing plaquenilPlaquenil and neurotransmitter acetylcholineHydroxychloroquine skin discolorationChloroquine diphophate salt Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. NAME OF MEDICATION COMMON BRAND NAMES USED TO TREAT. Common and Rare Side Effects for Plaquenil Oral. Did your muscle pain come before, after or with the neuropathy? Did the Plaquenil help with the muscle joint part of your problem? Where was your neuropathy and what are you taking now if anything? When I took the Plaquenil I had RA antibodies and it was muscle / joint related. Thanks for responding. I have been taking Plaquenil along with Methotrexate for about 17 years for rheumatoid arthritis. Around 2009 I began experiencing the symptoms of peripheral neuropathy DADS with Mag1 antibody and tests later proved that I did, indeed have this affliction. Including our patient, there are 10 reported cases of HCQ neuromyotoxicity. Muscle biopsy consistently reveals curvilinear bodies and muscle fiber atrophy with vacuolar changes. Most cases manifest as insidious onset proximal myopathy that may be associated with peripheral neuropathy and cardiac myotoxicity.