Mechanism of chloroquine resistance

Discussion in 'Hydroxychloroquine 200 Mg Tablet' started by anhydrous, 26-Feb-2020.

  1. Kroops User

    Mechanism of chloroquine resistance


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    Opens a new door to understanding the nature of chloroquine resistance. Here, I shall build on several recent reviews on the mechanism of chloroquine activity and resistance. and attempt to put the new findings into the context of our current understanding of chloroquine resistance development. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of chloroquine resistance

    Chloroquine - FDA prescribing information, side effects and uses, On the Mechanism of Chloroquine Resistance in Plasmodium falciparum

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  6. Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax. It is unknown if P. malariae or P. ovale has developed resistance to any antimalarial drugs.

    • Drug Resistance in the Malaria-Endemic World.
    • Drug Resistance in the Malaria-Endemic World - CDC.
    • Effects of chloroquine on viral infections an old drug..

    Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion. Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM

     
  7. Kopus New Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Too Little of a Good Thing Hydroxychloroquine in Pregnancy. Hydroxychloroquine Side Effects, Dosage, Uses, and More Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.
     
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  9. Amastreus XenForo Moderator

    Hydroxychloroquine in polymorphic light eruption a. Hydroxychloroquine in polymorphic light eruption a controlled trial with drug and visual sensitivity monitoring. Murphy GM, Hawk JL, Magnus IA. A double-blind controlled trial of oral hydroxychloroquine HC treatment in polymorphic light eruption PLE was completed in 13 patients on active treatment and 15 on placebo during June, July and.

    Hydroxychloroquine Professional Patient Advice -