Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Chloroquine 250 mg tablets Chloroquine retinopathy dose Methotrexate for Your RA. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will. I have had RA for 10 years and have been on Plaquenil pretty much the whole time. Methotrexate did not work for me and made me very nauseous. I also take 5-10 mg prednisone and an injection of Humira every week. I have had no side effects from the Plaquenil. Prednisone is a mean drug however, I can tell you this as a nurse too but I have to. To find out if methotrexate is a good choice for helping you manage your RA, talk to your doctor about whether it’s the right treatment for you individually. If you’re prescribed methotrexate, be sure to take it exactly as the doctor prescribes in the correct doses for maximum treatment benefits with the lowest risk of side effects. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate and plaquenil for ra Methotrexate vs plaquenil side effects long term and short term, Plaquenil for RA?" Rheumatoid Arthritis Community - Support Group Chloroquine parenteralChloroquine for malaria in pregnancyChloroquine elimination half life Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications Results of a two‐year, randomized, double‐blind, placebo‐controlled trial Treatment of rheumatoid arthritis with methotrexate and.. RA and Methotrexate Does Methotrexate Reduce Inflammation.. Combination therapy with methotrexate and hydroxychloroquine.. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate Rasuvo, Otrexup is a self-injectable solution used to treat psoriasis and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed.