Saposin b binds chloroquine

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by MVK2, 04-Mar-2020.

  1. netdancer Guest

    Saposin b binds chloroquine


    Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects.

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    I am also interested in the origins of drug toxicity as it pertains to lysosomal Saposin proteins see Tinklepaugh J, Smith BM, Hanlon E, Zubieta C, Bou-Abdallah F, Doyle RP. Exploring the Multi-ligand Binding Specificity of Saposin B Reveals Two Binding Sites. ACS Omega. The Lysosomal Protein Saposin B Binds Chloroquine. Huta BP, Mehlenbacher MR, Nie Y, Lai X, Zubieta C, Bou-Abdallah F, Doyle RP ChemMedChem, 113277-282, Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation; The Lysosomal Protein Saposin B Binds Chloroquine; Education Ph. D. “Biophysical Chemistry”, University of Paris 7-France 2000 Pre-Doctoral Degree DEA, Ecole Normale Superieure de Cachan ENSC, Paris-France 1997 M. S. Chemistry, Lebanese.

    While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone.

    Saposin b binds chloroquine

    The Lysosomal Protein Saposin B Binds Chloroquine., Chloroquine poisoning. Rapidly fatal without treatment.

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  3. Structure of saposin B in complex with chloroquine. Note Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds.

    • RCSB PDB - 4V2O Structure of saposin B in complex with..
    • Dr. F. Bou-Abdallah.
    • Chloroquine - Wikipedia.

    About. My previous research experiences focused on Metal-citrate transport in K. radiotolerans, investigating the binding of human Saposin B to antimalarial drugs, the total synthesis of 8,16. This thesis seeks to address the binding behavior and functionality of the lysosomal sphingolipid activator protein saposin B sapB. SapB is critical for the degradation of O-sulfogalactosylceramide by arylsulfatase A and deficiency of sapB leads to a variant form of the fatal lysosomal storage disease Metachromatic leukodystrophy. Discussed in this thesis is the ability of sapB to bind a. Peer-Reviewed Papers by SUNY Potsdam Undergraduates Mehlenbacher, M.*, Poli, M. Arosio, P. Santambrogio, P. Levi, S. Chasteen, N. D. Bou-Abdallah, F. Iron.

     
  4. eugene20072008 XenForo Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Uses, Dosage & Side Effects - Lupus Medicines Hydroxychloroquine - Brigham and Women's Hospital Lupus Medicines Hydroxychloroquine - Brigham and Women's.
     
  5. asfodel Well-Known Member

    Hydroxychloroquine Sulfate Neuropathy Peripheral Reports. Plaquenil “ Side Effects Stomach cramping, diarrhea, mild to severe headaches, dizziness, bloating, gas, loss of appetite and nausea. After having a terrible 4yr battle with debilitating fatigue, join.

    A Rare but Reversible Cause of Myopathy Hydroxychloroquine.