Chloroquine and cancer stem cells

Discussion in 'Hydroxychloroquine Sulfate' started by Larpseape, 02-Mar-2020.

  1. Chloroquine and cancer stem cells


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    Chloroquine eliminates pancreatic cancer stem cells In an effort to identify more effective treatments against pancreatic CSCs, we established a novel low-throughput drug-screening platform for identifying compounds targeting CSCs unpublished observations; Irene Miranda-Lorenzo. Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling Article PDF Available in Molecular Cancer Therapeutics 137 April 2014 with 251 Reads Pancreatic cancer cell line PaTu II 12, the effects of chloroquine on tumor growth were later. confirmed in mouse models of PDAC and attributed to the inhibition of autophagy 13, which is. responsible for recycling bioenergetic components to ensure cell survival in nutrient-deprived. times or locations 13.

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    Chloroquine and cancer stem cells

    Chloroquine in Cancer Therapy A Double-Edged Sword of., PDF Chloroquine Targets Pancreatic Cancer Stem Cells via.

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  7. Chloroquine eliminates pancreatic cancer stem cells. In an effort to identify more effective treatments against pancreatic CSCs, we established a novel low-throughput drug-screening platform for identifying compounds targeting CSCs unpublished observations; Irene Miranda-Lorenzo.

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    • PDF Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition..
    • Chloroquine eliminates cancer stem cells through deregulation..

    Jul 01, 2016 Chloroquine CQ eliminates cancer stem cell CSC subpopulations in TNBC. CQ causes structural mitochondrial damage, resulting in oxidative DNA breaks. CQ hinders the homologous recombination necessary for DNA break repair in CSCs. The goal of this review is to examine more recently reported roles for autophagy in cancer stem cells CSCs, tumor cell dormancy and related mechanisms of cancer drug resistance. GIST cells with Imatinib™ and inhibition of autophagy, including with the lysosomotropic agent chloroquine CQ, caused tumor cell apoptosis 114. Because autophagy seems to contribute to promote cancer, chloroquine may sensitize cancer cells through inhibiting autophagy. The dosage of chloroquine usually ranges between 100 and 500 mg/day. Side effects are minimal at low doses, while many more toxic effects occur at higher doses, such as visual disturbances, gastrointestinal upset, electrocardiographic changes, headache, and pruritus.

     
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    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine MedlinePlus Drug Information Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Pill Images White / Round -
     
  9. x-immortal User

    CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria Education and information regarding choosing a drug to prevent malaria, including a list of all available drugs and reasons for taking or not taking a certain drug.

    Chloroquine Dosage - Malaria Home Page