Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil radiation therapy Doctor took me off of plaquenil Hydroxychloroquine sulphate with leflunomide Jun 11, 2009 Retinal toxicity has been shown in patients taking greater than 3 mg/kg/day of chloroquine or 6.5 mg/kg/day of hydroxychloroquine. While most cases of toxicity have been reported for chloroquine, hydroxychloroquine has supplanted it as the more commonly used treatment agent for both RA and SLE. 2 Unfortunately, despite their many benefits, both medications, chloroquine Aralen or its analogue, hydroxychloroquine Plaquenil, carry with them a very small risk of permanent vision loss. Eye screening by an ophthalmologist is important to help identify any damage to the eye at the earliest stage possible. The tri-color macular image showed an inferior hemicircle of pigmentary mottling classic for hydroxychloroquine toxicity, but no obvious retinal detachment Figures Figures1 1 to to4. 4. Clinical exam revealed a shallow inferior retinal detachment. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil retinal detachment Causes of Retinal Detachment - 10FAQ, Plaquenil Toxicity - alberta- Stop antibodies drug plaquenilNbme 15 chloroquine Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions. How to Succeed in Plaquenil Screenings. Retinal Detachment in a Patient with Hydroxychloroquine Toxicity. Retinal Screening for Hydroxychloroquine Plaquenil Toxicity Retina.. The most common type of retinal detachment is a rhegmatogenous detachment usually due to an abnormal adherence of the vitreous gel to the retina, similar to wallpaper lining the inside wall of the eye. When the vitreous shrinks and separates, the abnormal adherence causes the retina to tear. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1.