Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Hydroxychloroquine long term use Plaquenil weight gain forum Can plaquenil cause a positive nicotine urine test Quinine sulfate allergy is it okay to take plaquenil Scleroderma is a rare condition, and patients with scleroderma need specialized care from a rheumatologist familiar with their condition. The care of patients with scleroderma requires a team approach. Many patients with scleroderma will input from different medical specialties including gastroenterology, pulmonary, cardiology, and others. May 18, 2019 Diagnosis. Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. After a thorough physical exam, your doctor may suggest blood tests to check for elevated levels of certain antibodies produced by the immune system. Scleroderma sklair-oh-DUR-muh is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues. Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. While there is no cure for scleroderma, a variety of treatments can ease symptoms and improve quality of life. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil Plaquenil for scleroderma? - Scleroderma - Inspire, Scleroderma - Diagnosis and treatment - Mayo Clinic Plaquenil treats celiac Systemic sclerosis scleroderma is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 10+ years, also take medication Lasix, and have Osteoporosis Will you have Systemic sclerosis scleroderma with Plaquenil - eHealthMe. Scleroderma - Symptoms and causes - Mayo Clinic. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. Scleroderma is thought to be an autoimmune disease. This means the symptoms are caused by the body attacking its own healthy tissues. Genes play a role in the disease, but the environment also plays a role. Family members of people with scleroderma have a mildly increased risk of developing scleroderma. Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs in addition to the skin. Scleroderma** is an chronic autoimmune connective tissue disease which causes an over-production of collagen. Its most visible symptom is the hardening of the skin. It is not contagious, infectious, or cancerous. There is more than one form of the disease, and the disease varies between patients. To date, there is no cure.