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    Cialis (tadalafil) treatment in older men with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) is less efficient but well-tolerated, a pool of Phase 2 and 3 clinical trials show. The analysis, “Efficacy and safety of tadalafil 5 mg once daily in the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia in men aged ≥75 years: integrated analyses of pooled data from multinational, randomized, placebo-controlled clinical studies,” appeared in the . Erectile dysfunction often coexists with LUTS/BPH and its incidence increases with LUTS severity. Despite an existing body of literature, effectiveness and safety data of various LUTS treatments for men 75 and older is non-existent. But as people age, altered pharmacology profiles associated with changes in organ blood flow and reduced organ function may affect drug efficacy. Among these agents, Cialis is a widely approved phosphodiesterase type 5 inhibitor used to treat LUTS/BPH, indicated in a 5 mg once a day dosing. The research team, led by Lars Viktrup, an MD and Ph D with Eli Lilly, the drug’s manufacturer, analyzed Cialis’ effectiveness and safety in men with LUTS/BPH as reported in previous clinical trials. Additional safety analysis was performed in men with erectile dysfunction. The erectile dysfunction drug Cialis (tadalafil) was approved by the Food and Drug Administration late Thursday for the treatment of urinary problems in men due to an enlarged prostate. But we still think other options, including lifestyle changes and, if necessary, inexpensive generic medications, should be tried first. Two studies cited by the FDA found that men with benign prostatic hyperplasia (BPH), who took Cialis got more relief from their urinary problems than those who took a placebo. A third study found that the medication also helped ease urinary problems in men who had both BPH and erectile dysfunction. BPH is usually not serious or life-threatening, but it can cause problems with urinating, such as difficulty starting or needing to go more often, primarily in men 50 and older. Bottom line: If you have urinary problems due to BPH, lifestyle changes should be tried first. Those include going to the bathroom when you first feel the urge, reducing your intake of alcohol and caffeine, and not drinking fluids just before bedtime.

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