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Definición Términos, palabras y expresiones incorporados al idioma español provenientes de idiomas indígenas. Click on the desired brand to find out the drug price. Information about drug Duloxetine includes cost of the drug and the type of drug. Deneurone 30 mg. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. 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