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The requirement of full antagonist activity for substantial side effect dissociation was demonstrated in primary human preadipocytes, hepatocytes, and osteoblasts in which effects on adipogenesis, key genes involved in gluconeogenesis, and genes important for bone formation were examined, respectively. The dissociated GR ligands, despite lacking significant reporter gene activation, weakly recruit a limited number of coactivators such as peroxisomal proliferator-activated receptor-γ coactivator 1α. Transcriptional activation was sensitive to both peroxisomal proliferator-activated receptor-γ coactivator 1α and GR levels, providing a basis for cell-selective modulation of gene expression. propecia bestellen Un arcaísmo se usa para designar un término léxico o un elemento gramatical que ha desaparecido del habla cotidiana, pero que es usado en ciertos contextos o entendido por los hablantes. En corto, arcaismos son palabras que generalmente son incorrectas pero aun son usadas. 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