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All of these medications may cause sedation (drowsiness) and impair cognitive function, seriously degrading pilot performance. This impairment can occur even when the individual feels alert and is apparently functioning normally - in other words, the airman can be "unaware of impair." For aviation safety, airmen should not fly following the last dose of any of the medications below until a period of time has elapsed equal to: Label warnings. Airmen should not fly while using any medication, prescription or OTC, that carries a label precaution or warning that it may cause drowsiness or advises the user "be careful when driving a motor vehicle or operating machinery." This applies even if label states "until you know how the medication affects you" and even if the airman has used the medication before with no apparent adverse effect. Alcohol is one of those substances that seems to clash with everything and anything. Alcohol contraindications refer to drugs that trigger a negative reaction when consumed with alcohol. These symptoms can range from sickness, nausea and allergic reactions, to drowsiness, sedation and loss of control (essentially an amplification of the alcohol effects). Perhaps most worryingly, there are also drugs that stop working or are less potent when consumed with alcohol. So, it’s important to understand what those contraindications are and that’s why we created this alcohol contraindications page to help you out. As mentioned above, there are alcohol contraindications that you really should be aware of. You should typically refrain from getting drunk when you are on medication, but you are usually okay to have a drink or two with some medications. 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