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    Sildenafil (brand name Viagra) is a phosphodiesterase 5 (PDE5) inhibitor. It is one of the Top 250 Drugs (similar to the Top 200 Drugs or Top 300 Drugs) in Clin Calc.com's Flash RX mobile app and The Top 250 Drugs online educational video course. Do you wish you could review the top 250 drugs from beginning to end? Sign up for our stellar online video series, The Top 250 Drugs. This course uses 60 succinct, high-yield videos and brief comprehension quizzes to help you develop a rock-solid understanding of the top 250 medications. viagra liver side effects If you said no, then you've definitely heard of Viagra, the brand name for the generic term of sildenafil. Viagra is used to treat erectile dysfunction (impotence). Another brand name version of sildenafil, Revatio, is used to manage pulmonary arterial hypertension (PAH), or high blood pressure (hypertension) in the arteries of the lungs ('pulmon-'). You can check out the structure of sildenafil in this lesson's image. And if you keep reading, you'll also learn exactly how it is that sildenafil works at treating both of these conditions. An erection occurs and disappears as a result of an interplay of forces. Not to be funny, just for simplicity's sake, we'll call the forces that lead to an erection as the good guys and the ones that cause one to disappear as the bad guys.

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    – The healthy brain is a master of autoregulation, continuously adjusting blood flow to meet metabolic demand. But in traumatic brain injury, cerebrovascular reactivity (CVR) breaks down; blood vessels don’t dilate as they should to deliver nutrients and oxygen, leading to progressive neurologic decline. Sildenafil (Viagra) – a vasodilator in injured blood vessels – might help, according to ongoing research at the University of Pennsylvania, Philadelphia. Researchers there to inpatients with persistent symptoms at least 6 months after traumatic brain injury and measured CVR by a novel MRI technique an hour later. “Sildenafil was able to correct the deficit in CVR in many cases. We are hopeful this could be a useful therapy,” said principal investigator at annual meeting of the American Neurological Association. The next step is to see if sildenafil helps CVR in acute traumatic brain injury, and in people who have had multiple, mild brain traumas, including professional athletes. To treat erectile dysfunction in males, that by suppressing a phosphodiesterase enzyme also suppresses the enzyme's inhibitory effect on the hormone cyclic GMP, and that enables the cyclic GMP produced during sexual arousal to initiate the muscular and vascular changes which produce an erection These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sildenafil.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Sildenafil inhibits a phosphodiesterase enzyme that degrades cyclic GMP. Higher levels of cyclic GMP in the body promote relaxation of smooth muscle, which allows for increased blood flow to the lungs to lower blood pressure and to the corpus cavernosum to produce an erection during sexual arousal. Sildenafil is marketed under the trademark Viagra to treat erectile dysfunction and under the trademark Revatio to treat pulmonary arterial hypertension.

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