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    The preparation recovers the normal reaction to sexual arousal. A physiological mechanism that ensures an erection is not possible without emitting of nitric oxide in cavernous body during sexual stimulation. NO activates a special enzyme called guanylate cyclase, as a result the level of cycle guanosine monophosphate (c GMP) is increased, muscles of the cavernous body relax and the blood flow is increased in a penis. Sildenafil, the active ingredient of VIAGRA, is selective inhibitor of PDE5 (phosphodiesterase type 5) that ensures the collapse of c GMP in the cavernous body. The drug is characterized by a peripheral effect on penile erection. It is noteworthy that sildenafil relaxes the cavernous body not directly, but by means of relaxing function of nitric oxide. It is known that the sexual stimulation is needed for a useful pharmacological action. Viagra returns lost sexual function and assists in stable erect to the men. The mechanism of erection is as follows: There are corpora cavernosa in the penis. In order to have an erection, they should be completely filled with blood. An extensive network of small arterioles is inside these corpora cavernosa , which are filled with blood during relaxation of the muscles of the penis. This is only possible in the presence of nitric oxide. The drug Viagra inhibits PDE5 substance and provides the erection. Please note: to have an effect from the drug, a man must be in a state of sexual arousal.

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